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HPE ProLiant DL380 Gen10 server
Where is your server bottlenecked...storage, compute, expansion?
The HPE ProLiant DL380 Gen10 server delivers the latest in security, performance and expandability, backed by a comprehensive warranty. Standardize on the industry's most trusted compute platform. The HPE ProLiant DL380 Gen10 server is securely designed to reduce costs and complexity, featuring the First and Second Generation Intel® Xeon® Processor Scalable processor with up to a 60% performance gain1 and 27% increase in cores2, plus the HPE 2933 MT/s DDR4 SmartMemory supporting 3.0 TB. It supports 12 Gb/s SAS, and up to 20 NVMe drive plus a broad range of compute options. Intel® Optane™ persistent memory 100 series for HPE offers unprecedented levels of performance for databases and analytic workloads. Run everything from the most basic to mission-critical applications and deploy with confidence.
QuickSpecs
QuickSpecs
QuickSpecs (PDF)
QuickSpecs (HTML)
DL380 Gen10 Windows File Solution
- Starting at 9.6TB (raw)
- XEON 4210R 10-core
- 2 x 32GB DIMM
- 4 x 2.4TB SAS HDD
- Windows 2019 Std
DL380 Gen10 VMware Virtualization Solution
- Ideal for up to 16 vCPUs
- XEON 4214R 12-core
- 12 x 32GB DIMM
- 5 x 2.4TB SAS HDD
- VMware vSphere Ess
DL380 Gen10 VMware Horizon Large VDI Solution
- Ideal for 38 users
- XEON 5218 16-core
- 6 x 32GB DIMM
- 3 x 960GB SATA SSD
- VMware Horizon
DL380 Gen10 Windows Virtualization Solution
- Ideal for up to 16 vCPUs
- XEON 4214R 12-core
- 12 x 32GB DIMM
- 5 x 2.4TB SAS HDD
- Windows 2019 DC
Want to configure your own?
ConfigurationsHPE ProLiant DL380 Gen10 6242 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P40428-B21
- Intel® Xeon® Scalable 6242 (16 core, 2.8GHz, 22 MB, 150W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6250 1P 32GB-R S100i NC 8SFF 800W PS Server
P40427-B21
- Intel® Xeon® Scalable 6250 (8 core, 3.9 GHz, 35.75 MB, 185W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6248R 1P 32GB-R S100i NC 8SFF 800W PS Server
P40426-B21
- Intel® Xeon® Scalable 6248R (24 core, 3.0 GHz, 35.75 MB, 205W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4215R 1P 32GB-R S100i NC 8SFF 800W PS Server
P40425-B21
- Intel® Xeon® Scalable 4215R (8 core, 3.2 GHz, 8.25 MB, 130W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6234 1P 32GB-R S100i NC 8SFF 800W PS Server
P40424-B21
- Intel® Xeon® Scalable 6234 (8 core, 3.3 GHz, 24.75 MB, 130W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5222 1P 32GB-R S100i NC 8SFF 800W PS Server
P40422-B21
- Intel® Xeon® Scalable 5222 (4 core, 3.8 GHz, 16.5 MB, 105W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6226R 1P 32GB-R S100i NC 8SFF 800W PS Server
P40423-B21
- Intel® Xeon® Scalable 6226R (16 core, 2.9 GHz, 22 MB, 150W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5220 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P39380-B21
- Intel® Xeon® Scalable 5220 (18 core, 2.2 GHz, 24.75 MB, 125W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5218R 1P 32GB-R S100i NC 8SFF 800W PS Server
P36135-B21
- Intel® Xeon® Scalable 5218R (16 core, 2.3 GHz. 27.5 MB, 125W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6250 1P 32GB-R S100i NC 8SFF 800W PS Server
P24850-B21
- Intel® Xeon® Scalable 6250 (8 core, 3.9 GHz, 35.75 MB, 185W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6248R 1P 32GB-R S100i NC 8SFF 800W PS Server
P24849-B21
- Intel® Xeon® Scalable 6248R (24 core, 3.0 GHz, 35.75 MB, 205W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4215R 1P 32GB-R S100i NC 8SFF 800W PS Server
P24848-B21
- Intel® Xeon® Scalable 4215R (8 core, 3.2 GHz, 8.25 MB, 130W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6234 1P 32GB-R S100i NC 8SFF 800W PS Server
P24847-B21
- Intel® Xeon® Scalable 6234 (8 core, 3.3 GHz, 24.75 MB, 130W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5222 1P 32GB-R S100i NC 8SFF 800W PS Server
P24845-B21
- Intel® Xeon® Scalable 5222 (4 core, 3.8 GHz, 16.5 MB, 105W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5218R 1P 32GB-R S100i NC 8SFF 800W PS Server
P24844-B21
- Intel® Xeon® Scalable 5218R (16 core, 2.3 GHz. 27.5 MB, 125W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6226R 1P 32GB-R S100i NC 8SFF 800W PS Server
P24846-B21
- Intel® Xeon® Scalable 6226R (16 core, 2.9 GHz, 22 MB, 150W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 6242 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P20245-B21
- Intel® Xeon® Scalable 6242 (16 core, 2.8GHz, 22 MB, 150W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4214R 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P24842-B21
- Intel® Xeon® Scalable 4210R (10 core, 2.4 GHz, 13.75 MB, 100W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4210R 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P24841-B21
- Intel® Xeon® Scalable 4210R (10 core, 2.4 GHz, 13.75 MB, 100W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4210R 1P 32GB-R P408i-a NC 24SFF 800W PS Server
P24840-B21
- Intel® Xeon® Scalable 4210R (10 core, 2.4 GHz, 13.75 MB, 100W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 24 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4210 1P 32GB-R P408i-a NC 8SFF 500W PS Server
P20174-B21
- Intel® Xeon® Scalable 4210 (10 core, 2.2 GHz, 10 MB, 85W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 500W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
HPE ProLiant DL380 Gen10 4208 1P 32GB-R P816i-a NC 12LFF 800W RPS Server
P20172-B21
- Intel® Xeon® Scalable 4208 (8 core, 2.1 GHz, 11 MB, 85W)
- 32 GB (1x 32 GB) RDIMM
- None ship standard, 12 LFF drives supported
- 2 HPE 800W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
HPE ProLiant DL380 Gen10 3204 1P 16GB-R S100i NC 8LFF 500W PS Server
P20182-B21
- Intel® Xeon® Scalable 3204 (8 core, 1.9 GHz, 8.25 MB, 85W)
- 16 GB (1x 16 GB) RDIMM
- None ship standard, 8 LFF drives supported
- 1 HPE 500W Flex Slot Universal Hot Plug Low Halogen Power Supply Kit
HPE ProLiant DL380 Gen10 5220 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P20248-B21
- Intel® Xeon® Scalable 5220 (18 core, 2.2 GHz, 24.75 MB, 125W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 5218 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P20249-B21
- Intel® Xeon® Scalable 4210R (10 core, 2.4 GHz, 13.75 MB, 100W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4214 1P 16GB-R P816i-a 12LFF 800W PS Server
P02468-B21
- Intel® Xeon® Scalable 4214 (12 core, 2.2 GHz, 16.5 MB, 85W)
- 16 GB (1 x 16 GB) RDIMM Dual Rank 2933MT/s
- None ship standard, 12 LFF SAS/SATA drives supported
- 1 HPE 800W Flex Slot Platinum hot plug power supply
HPE ProLiant DL380 Gen10 4210R 2.4GHz 10-core 1P 32GB-R P408i-a 8SFF 800W PS Server
P50751-B21
- Intel® Xeon® Scalable 4210R (10 core, 2.4 GHz, 13.75 MB, 100W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4215R 3.2GHz 8-core 1P 32GB-R P408i-a NC 8SFF 800W PS Server
P40717-B21
- Intel® Xeon® Scalable 4215R (8 core, 3.2 GHz, 8.25 MB, 130W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 800W Flex Slot Universal Hot Plug Low Halogen
HPE ProLiant DL380 Gen10 4208 1P 32GB-R P408i-a NC 8SFF 500W PS Server
P23465-B21
- Intel® Xeon® Scalable 4208 (8 core, 2.1 GHz, 11 MB, 85W)
- 32 GB (1x 32GB) RDIMM
- None ship standard, 8 SFF drives supported
- 1 HPE 500W Flex Slot Universal Hot Plug Low Halogen
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More Information
What's New
- Defend applications and data before your server is built with the new HPE Trusted Supply Chain offering.
- Supporting additional second generation Intel® Xeon® Scalable processor family offerings.
- Increased Single-Width GPU Density with up to 7 NVIDIA Tesla T4 16GB Computational Accelerators or 7 Xilinx Alveo U50 Accelerators supported in a standard-depth 2U rack form factor
- Networking Choice (NC) server models provide greater flexibility in the primary networking selection.
- Intel® Optane™ persistent memory 100 series for HPE offers the flexibility to deploy as dense memory or fast storage and enables per-socket memory capacity of up to 3.0 TB.3
- iLO 5 security enhancements: Server Configuration Lock, iLO Security Dashboard and Workload Performance Advisor. HPE InfoSight provides cloud-based analytics to predict and prevent issues proactively.
Key Features
Defend Applications and Data Before Your Server is Built with HPE Trusted Supply Chain
A new first line of defense against cyber-attackers with select servers built to the world’s toughest security standards in secured facilities, bringing together security, processes and people to deliver protection for your most sensitive applications and data even before your server is built.
Built in secure HPE facilities to the most stringent Country of Origin USA and conformance requirements, HPE Trusted Supply Chain servers are inspected to be free from malicious microcode and counterfeit parts, safeguarding it against cyber-exploits throughout its life cycle.
With hardened security built in, HPE Trusted Supply Chain hardens the protections designed into select HPE products with unrivaled supply chain visibility and standards compliance providing a 360-degree view and mitigation plan for current and emerging cyber-threats.
Allied to ensure authenticity, HPE Trusted Supply Chain doubles down on your protection with vetted HPE employees assigned to the product build to manage the product manufacturing process that adheres to the strictest sourcing, inspection and traceability standards.
Learn more about HPE Trusted Supply Chain
World-Class Performance featuring Enhanced Compute Density
The ProLiant DL380 now features significantly enhanced GPU density, expanding support from five to seven Full-Height, Half-Length, Single-Width Accelerators/GPUs; or up to six in a balanced configuration with additional PCIe expansion via the tertiary riser.
Leveraging HPE's most popular 2U rackmount server, fitting standard depth racks, customers can benefit from one of the densest Accelerator/GPU platforms with an extensive set of Accelerator options, enabling diverse cloud workload performance and optimization of AI and deep learning experiences.
Supported on the ProLiant DL380, the NVIDIA T4 GPU is ideal for Deep learning, Inferencing, Machine Learning, HPC, Rendering, VDI, Virtual Workstations and combinations thereof for mixed workloads - maximizing utilization of data center resources and lowering TCO.
Flexible Design Making Your Investment Expand As Your Business Needs Grow
The HPE ProLiant DL380 Gen10 server has an adaptable chassis, including new Hewlett Packard Enterprise modular drive bay configuration options with up to 30 SFF, up to 19 LFF or up to 20 NVMe drive options along with support for up to three double wide GPU options.
Adapting and growing to changing business needs, Networking Choice (NC) server models provide flexibility in the primary networking choice while Embedded LOM server models offer an embedded 4x1GbE by default; both provide network options (1GbE to 100GbE) via HPE FlexibleLOM or PCIe standup adapters.
HPE Persistent Memory works with DRAM to provide fast, high capacity, cost effective memory and storage to transform big data workloads and analytics by enabling data to be stored, moved, and processed quickly.
In conjunction with the embedded SATA HPE Dynamic Smart Array S100i Controller for boot, data and media needs, the redesigned HPE Smart Array Controllers allow you the flexibility to choose the optimal 12 Gb/s controller most suited to your environment, and operate in both SAS and HBA mode.
Supporting a wide range of operating environments from Azure to Docker to ClearOS in addition to traditional operating systems.
Industry Leading Services and Ease of Deployment
The HPE ProLiant DL380 Gen10 server comes with a complete set of HPE Technology Services, delivering confidence, reducing risk, and helping customers realize agility and stability.
HPE Pointnext Services simplifies all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an optimal solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.
A suite of embedded and downloadable tools is available for server lifecycle management including Unified Extensible Firmware Interface (UEFI), Intelligent Provisioning; HPE iLO 5 to monitor and manage; HPE iLO Amplifier Pack, Smart Update Manager (SUM), and Service Pack for ProLiant (SPP).
Hewlett Packard Enterprise IT investment solutions help you transform to a digital business with IT economics that align to your business goals.
1 HPE measurements: Up to 60% performance increase of Intel Xeon Platinum vs. previous generation E5-2600 v4 average gains of STREAM, LINPACK, SPEC CPU 2006 & SPEC CPU2017 metrics on HPE servers comparing 2-socket Intel Xeon Platinum 8280 to E5-2699 v4 family processors. Any difference in system hardware or software design or configuration may affect actual performance. April 2019.
2 Up to 27% cores increase of Intel Xeon Platinum vs. previous generation comparing 2-socket Intel Xeon Platinum 8280 (28 cores) to E5-2699 v4 (22 cores). Calculation 28 cores/22 cores= 1.27 = 27%. April 2019.
3 3.0 TB per socket with 512GB 2666 Persistent Memory Kit
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Intel Xeon and Intel are trademarks of Intel Corporation in the U.S. and other countries. Microsoft and Azure are registered trademarks of Microsoft Corporation in the United States and other countries. All other third-party trademark(s) is/are property of their respective owner(s).
* Prices may vary based on local reseller.
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